Improving Min Hash for Metagenomic Classification

This work improves upon the so called "min hash" technique (a "probabilistic data analysis" method) to develop a very fast and efficient way to estimate the similarity of two sets of objects (in terms of how much they overlap). The approach we present is orders of magnitude faster (and uses orders of magnitude less space) when two data sets under consideration are of very different size. The kinds of sets we consider are sets of sub-strings (called k-mers) of DNA sequences from communities of microorganisms.

IndeCut evaluates performance of network motif discovery algorithms

A gene regulatory network is basically a representation of how genes interact with each other. In this work, we develop the only (to date) method to assess the accuracy of so called "motif discovery algorithms" that seek to find important sub-networks of a given gene regulatory network. We develop a provably correct mathematical approach (based on a variety of metrics that say how close two matrices are to each other) and use this to assess the performance of a variety of motif discovery algorithms.

Dissertation

This is my PhD thesis from Penn State (advised by Manfred Denker).

Topological entropy of DNA sequences

I define a new notion of "randomness" (called topological pressure) suitable for use on sequences of symbols (words) of finite length. I show that this can be used to distinguish between biologically interesting sequences in the human genome.

Quikr: a method for rapid reconstruction of bacterial communities via compressive sensing

We introduce an extremely fast, light-weight, "big data" algorithm to quickly answer the question of "which bacteria are present?" in a given sample of DNA. The method is based on the theory of compressed sensing and aims to find the simplest explanation for the data in terms of known information.

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